The pipeline, measured
Pick a pipeline. The ring is graduated to its published length, and each phase sits where the sources put it. Where they don't pin a phase down, the ring says approx.
Each tick is a locus from our list, placed at the phase where a published study ties it to a stressor that phase carries, such as cold water, sleep loss, or load on bone and soft tissue. Longer ticks mean stronger evidence. Where no locus clears our bar, there is no tick. Breath-hold and swimming volume have none in rev. 1.0, so the dive weeks are mostly bare.
BUD/S · Ticks on this ring, by phase
- Orientation wk 1–7 · NSWO: ACE rs4343 (running volume), Grade C; PPARGC1A rs8192678 (running volume), Grade C; COL5A1 rs12722 (running volume), Grade C; MMP3 rs679620 (running volume), Grade C; GDF5 rs143383 (running volume), Grade C; TMPRSS6 rs855791 (running volume), Grade B; ACTN3 rs1815739 (soft-tissue load), Grade C; COL1A1 rs1800012 (soft-tissue load), Grade C
- First Phase wk 1–3 · Pre-Hell Week: FKBP5 rs1360780 (acute stress), Grade C; NR3C1 rs41423247 (acute stress), Grade C; ACE rs4343 (running volume), Grade C; PPARGC1A rs8192678 (running volume), Grade C; COL5A1 rs12722 (running volume), Grade C; MMP3 rs679620 (running volume), Grade C; GDF5 rs143383 (running volume), Grade C; TMPRSS6 rs855791 (running volume), Grade B; ACTN3 rs1815739 (cold water), Grade C; COL1A1 rs1800012 (soft-tissue load), Grade C; GC rs2282679 (bone load), Grade B; CYP2R1 rs10741657 (bone load), Grade B; DHCR7/NADSYN1 rs12785878 (bone load), Grade B; WNT16 rs2707466 (bone load), Grade B; LRP5 rs3736228 (bone load), Grade B; P2RX7 rs3751143 (bone load), Grade C; P2RX7 rs1718119 (bone load), Grade C
- First Phase wk 4 · Hell Week: COMT rs4680 (sleep loss), Grade C; TNF rs1800629 (sleep loss), Grade C; ADA rs73598374 (sleep loss), Grade C; BDNF rs6265 (sleep loss), Grade C; CYP1A2 rs762551 (caffeine response), Grade C; ADORA2A rs5751876 (caffeine response), Grade B; AHR rs4410790 (caffeine response), Grade B; ACTN3 rs1815739 (cold water), Grade C; FKBP5 rs1360780 (acute stress), Grade C; NR3C1 rs41423247 (acute stress), Grade C; COL1A1 rs1800012 (soft-tissue load), Grade C; COL5A1 rs12722 (soft-tissue load), Grade C; MMP3 rs679620 (soft-tissue load), Grade C; GDF5 rs143383 (soft-tissue load), Grade C
- First Phase wk 5–7 · Post-Hell Week: ADA rs73598374 (recovery), Grade C; BDNF rs6265 (recovery), Grade C; ACE rs4343 (running volume), Grade C; PPARGC1A rs8192678 (running volume), Grade C; COL5A1 rs12722 (running volume), Grade C; MMP3 rs679620 (running volume), Grade C; GDF5 rs143383 (running volume), Grade C; TMPRSS6 rs855791 (running volume), Grade B
- Second Phase wk 1–7 · Combat diving: ACTN3 rs1815739 (cold water), Grade C; FKBP5 rs1360780 (acute stress), Grade C; NR3C1 rs41423247 (acute stress), Grade C
- Third Phase wk 1–7 · Land warfare: ACE rs4343 (loaded rucking), Grade C; TMPRSS6 rs855791 (loaded rucking), Grade B; PPARGC1A rs8192678 (running volume), Grade C; COL5A1 rs12722 (running volume), Grade C; MMP3 rs679620 (running volume), Grade C; GDF5 rs143383 (running volume), Grade C; ACTN3 rs1815739 (soft-tissue load), Grade C; COL1A1 rs1800012 (soft-tissue load), Grade C
24 of 24 loci fall on this ring.
SFAS · Ticks on this ring, by phase
- SFAS wk 1 · Individual assessment, approx.: ACE rs4343 (running volume), Grade C; PPARGC1A rs8192678 (running volume), Grade C; COL5A1 rs12722 (running volume), Grade C; MMP3 rs679620 (running volume), Grade C; GDF5 rs143383 (running volume), Grade C; TMPRSS6 rs855791 (running volume), Grade B; ACTN3 rs1815739 (soft-tissue load), Grade C; COL1A1 rs1800012 (soft-tissue load), Grade C; FKBP5 rs1360780 (acute stress), Grade C; NR3C1 rs41423247 (acute stress), Grade C
- SFAS wk 2 · Land navigation, approx.: ACE rs4343 (loaded rucking), Grade C; TMPRSS6 rs855791 (loaded rucking), Grade B; COMT rs4680 (sleep loss), Grade C; TNF rs1800629 (sleep loss), Grade C; ADA rs73598374 (sleep loss), Grade C; BDNF rs6265 (sleep loss), Grade C; CYP1A2 rs762551 (caffeine response), Grade C; ADORA2A rs5751876 (caffeine response), Grade B; AHR rs4410790 (caffeine response), Grade B; FKBP5 rs1360780 (acute stress), Grade C; NR3C1 rs41423247 (acute stress), Grade C; ACTN3 rs1815739 (soft-tissue load), Grade C; COL1A1 rs1800012 (soft-tissue load), Grade C; COL5A1 rs12722 (soft-tissue load), Grade C; MMP3 rs679620 (soft-tissue load), Grade C; GDF5 rs143383 (soft-tissue load), Grade C
- SFAS wk 3 · Team week, approx.: ACE rs4343 (loaded rucking), Grade C; TMPRSS6 rs855791 (loaded rucking), Grade B; COMT rs4680 (sleep loss), Grade C; TNF rs1800629 (sleep loss), Grade C; ADA rs73598374 (sleep loss), Grade C; BDNF rs6265 (sleep loss), Grade C; CYP1A2 rs762551 (caffeine response), Grade C; ADORA2A rs5751876 (caffeine response), Grade B; AHR rs4410790 (caffeine response), Grade B; FKBP5 rs1360780 (acute stress), Grade C; NR3C1 rs41423247 (acute stress), Grade C; ACTN3 rs1815739 (soft-tissue load), Grade C; COL1A1 rs1800012 (soft-tissue load), Grade C; COL5A1 rs12722 (soft-tissue load), Grade C; MMP3 rs679620 (soft-tissue load), Grade C; GDF5 rs143383 (soft-tissue load), Grade C
17 of 24 loci fall on this ring.
RASP · Ticks on this ring, by phase
- RASP wk 1–2 · Peak assessment: FKBP5 rs1360780 (acute stress), Grade C; NR3C1 rs41423247 (acute stress), Grade C; ACE rs4343 (loaded rucking), Grade C; TMPRSS6 rs855791 (loaded rucking), Grade B; ACTN3 rs1815739 (soft-tissue load), Grade C; COL1A1 rs1800012 (soft-tissue load), Grade C; COL5A1 rs12722 (soft-tissue load), Grade C; MMP3 rs679620 (soft-tissue load), Grade C; GDF5 rs143383 (soft-tissue load), Grade C; PPARGC1A rs8192678 (running volume), Grade C
- RASP wk 3–5 · Assessment: ACE rs4343 (loaded rucking), Grade C; TMPRSS6 rs855791 (loaded rucking), Grade B; PPARGC1A rs8192678 (running volume), Grade C; COL5A1 rs12722 (running volume), Grade C; MMP3 rs679620 (running volume), Grade C; GDF5 rs143383 (running volume), Grade C; ACTN3 rs1815739 (soft-tissue load), Grade C; COL1A1 rs1800012 (soft-tissue load), Grade C; FKBP5 rs1360780 (acute stress), Grade C; NR3C1 rs41423247 (acute stress), Grade C
- RASP wk 6–8 · Skills training: ACE rs4343 (loaded rucking), Grade C; TMPRSS6 rs855791 (loaded rucking), Grade B; ACTN3 rs1815739 (soft-tissue load), Grade C; COL1A1 rs1800012 (soft-tissue load), Grade C; COL5A1 rs12722 (soft-tissue load), Grade C; MMP3 rs679620 (soft-tissue load), Grade C; GDF5 rs143383 (soft-tissue load), Grade C; FKBP5 rs1360780 (acute stress), Grade C; NR3C1 rs41423247 (acute stress), Grade C
10 of 24 loci fall on this ring.
A&S · Ticks on this ring, by phase
- A&S wk 1–2 · Phase I screening: ACE rs4343 (loaded rucking), Grade C; TMPRSS6 rs855791 (loaded rucking), Grade B; PPARGC1A rs8192678 (running volume), Grade C; COL5A1 rs12722 (running volume), Grade C; MMP3 rs679620 (running volume), Grade C; GDF5 rs143383 (running volume), Grade C; ACTN3 rs1815739 (soft-tissue load), Grade C; COL1A1 rs1800012 (soft-tissue load), Grade C
- A&S wk 3–5 · Phase II selection, approx.: FKBP5 rs1360780 (acute stress), Grade C; NR3C1 rs41423247 (acute stress), Grade C; ACE rs4343 (loaded rucking), Grade C; TMPRSS6 rs855791 (loaded rucking), Grade B
10 of 24 loci fall on this ring.
PJ/CCT · Ticks on this ring, by phase
- SWCC wk 1–6 · Conditioning, approx.: ACE rs4343 (running volume), Grade C; PPARGC1A rs8192678 (running volume), Grade C; COL5A1 rs12722 (running volume), Grade C; MMP3 rs679620 (running volume), Grade C; GDF5 rs143383 (running volume), Grade C; TMPRSS6 rs855791 (running volume), Grade B; ACTN3 rs1815739 (soft-tissue load), Grade C; COL1A1 rs1800012 (soft-tissue load), Grade C
- SWCC wk 7 · Resiliency event, approx.: COMT rs4680 (sleep loss), Grade C; TNF rs1800629 (sleep loss), Grade C; ADA rs73598374 (sleep loss), Grade C; BDNF rs6265 (sleep loss), Grade C; CYP1A2 rs762551 (caffeine response), Grade C; ADORA2A rs5751876 (caffeine response), Grade B; AHR rs4410790 (caffeine response), Grade B; FKBP5 rs1360780 (acute stress), Grade C; NR3C1 rs41423247 (acute stress), Grade C; ACTN3 rs1815739 (soft-tissue load), Grade C; COL1A1 rs1800012 (soft-tissue load), Grade C; COL5A1 rs12722 (soft-tissue load), Grade C; MMP3 rs679620 (soft-tissue load), Grade C; GDF5 rs143383 (soft-tissue load), Grade C
- A&S wk 1–4 · Assessment and selection: FKBP5 rs1360780 (acute stress), Grade C; NR3C1 rs41423247 (acute stress), Grade C; ACE rs4343 (loaded rucking), Grade C; TMPRSS6 rs855791 (loaded rucking), Grade B; ACTN3 rs1815739 (soft-tissue load), Grade C; COL1A1 rs1800012 (soft-tissue load), Grade C; COL5A1 rs12722 (soft-tissue load), Grade C; MMP3 rs679620 (soft-tissue load), Grade C; GDF5 rs143383 (soft-tissue load), Grade C; ADA rs73598374 (recovery), Grade C; BDNF rs6265 (recovery), Grade C
17 of 24 loci fall on this ring.